1. Sudoku Topology - Thinky Games
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Handcrafted Sudoku puzzles on strangely-shaped 3D grids.
2. Sudoku Topology • GameLog • Le backlog du gamer organisé
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Sudoku Topology : infos jeu vidéo & statistiques
3. [PDF] Analysis of nonsimple Nonograms Philippe P. Bors
In this subchapter we introduce a solving strategy based on 2-satisfiability, as well as a polynomial algorithm that can determine if a puzzle encapturing all ...
4. [PDF] Machine Learning of Implicit Combinatorial Rules in Mechanical ...
Here we show that convolutional neural networks can learn to recognize these boundaries for combinatorial mechanical metamaterials, down to finest detail, ...
5. Re-Arranging the Puzzle between the Amyloid-Beta and Tau Pathology
Sign In / Sign Up. Notice. You can make submissions to other journals here ... International Journal of Topology, International Journal of Translational ...
After several years of research in the field of Alzheimer’s disease (AD), it is still unclear how amyloid-beta (Aβ) and Tau, two key hallmarks of the disease, mediate the neuropathogenic events that lead to AD. Current data challenge the “Amyloid Cascade Hypothesis” that has prevailed in the field of AD, stating that Aβ precedes and triggers Tau pathology that will eventually become the toxic entity in the progression of the disease. This perspective also led the field of therapeutic approaches towards the development of strategies that target Aβ or Tau. In the present review, we discuss recent literature regarding the neurotoxic role of both Aβ and Tau in AD, as well as their physiological function in the healthy brain. Consequently, we present studies suggesting that Aβ and Tau act independently of each other in mediating neurotoxicity in AD, thereafter, re-evaluating the “Amyloid Cascade Hypothesis” that places Tau pathology downstream of Aβ. More recent studies have confirmed that both Aβ and Tau could propagate the disease and induce synaptic and memory impairments via the amyloid precursor protein (APP). This finding is not only interesting from a mechanistic point of view since it provides better insights into the AD pathogenesis but also from a therapeutic point of view since it renders APP a common downstream effector for both Aβ and Tau. Subsequently, therapeutic strategies that act on APP might provide a more viable and physiologically relevant approach for targeti...
6. Inverting the Topology of a Transmembrane Protein by ...
4 aug 2016 · Stimulation of cells with either transforming-growth factor β (TGF-β) ... (B) A549/pTM4SF20 cells were set up and treated as described in Figure 5A ...
TM4SF20 (transmembrane 4 L6 family 20) is a polytopic membrane protein that inhibits proteolytic processing of CREB3L1 (cAMP response element-binding protein 3-like 1), a membrane-bound transcription factor that blocks cell division and activates ...
7. An idealised approach of geometry and topology to the diffusion of ...
6 aug 2020 · We apply minimal coupling procedure when considering curved space-time. The model. A theoretical model of a multi-layered material with lattice ...
Honeycomb layered oxides are a novel class of nanostructured materials comprising alkali or coinage metal atoms intercalated into transition metal slabs. The intricate honeycomb architecture and layered framework endows this family of oxides with a tessellation of features such as exquisite electrochemistry, unique topology and fascinating electromagnetic phenomena. Despite having innumerable functionalities, these materials remain highly underutilised as their underlying atomistic mechanisms are vastly unexplored. Therefore, in a bid to provide a more in-depth perspective, we propose an idealised diffusion model of the charged alkali cations (such as lithium, sodium or potassium) in the two-dimensional (2D) honeycomb layers within the multi-layered crystal of honeycomb layered oxide frameworks. This model not only explains the correlation between the excitation of cationic vacancies (by applied electromagnetic fields) and the Gaussian curvature deformation of the 2D surface, but also takes into consideration, the quantum properties of the cations and their inter-layer mixing through quantum tunnelling. Through this work, we offer a novel theoretical framework for the study of multi-layered materials with 2D cationic diffusion currents, as well as providing pedagogical insights into the role of topological phase transitions in these materials in relation to Brownian motion and quantum geometry.
8. Königsberg bridge problem | Mathematics, Graph Theory ...
8 nov 2024 · Königsberg bridge problem, a recreational mathematical puzzle, set ... The connection between graph theory and topology led to a subfield called ...
Königsberg bridge problem, a recreational mathematical puzzle, set in the old Prussian city of Königsberg (now Kaliningrad, Russia), that led to the development of the branches of mathematics known as topology and graph theory. In the early 18th century, the citizens of Königsberg spent their days
9. [PDF] Operator Theoretic Aspects of Ergodic Theory - Analysis
21 jul 2012 · ... topology and set theory, even mathematical logic. Right from the beginning, also operator the- ory (which for the sake of simplicity we use ...
10. TREE-PUZZLE
TREE-PUZZLE is a computer program to reconstruct phylogenetic trees from molecular sequence data by maximum likelihood.
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11. topological insights from the chinese rings
6 sep 2001 · (Recall that we consider the arc A up to homotopy only.) The benefit of this trick is that the modified puzzle is much easier to solve.
